الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
DM is a chronic disease with rapidly rising burden. Current projections estimate the global prevalence of diabetes to rise from 6.4% (285 million) in 2010 to 7.7% (439 million) in 2030. DM results in both microvascular and macrovascular complications. DN is one of the most serious microvascular complications
DN is defined as clinically persistent detection of proteinuria linked to elevation of BP and decreased GFR. DN expressed first by the presence of micro- albuminuria (30-300 mg /gm ) and then by macro-albuminuria (>300 mg /gm) and eventually progression to ESRD.
Many lines of evi¬dence show that inflammatory pathways have a central role in the development of DN. The relationships between inflammation and the development and progression of DN involve complex molecular networks and processes.
Understanding of the roles that these inflammatory pathways have in the context of DN will facilitate the discovery of new biomarkers and therapeutic targets. Among proinflammatory molecules and pathways implicated in the development and progression of DN is TWEAK/Fn14 pathway.
This study is designed as cross sectional descriptive study which enrolled 80 subjects who were divided into 3 main groups, the first group diabetic with ACR > 30 mg / gm was 30 subjects which is further divided into 2 subgroups (20 micro-albuminuric group with ACR 30-300 mg/ gm and 10 macro-albuminuric goup with ACR >300 mg / gm) , the second group diabetic with ACR <30 mg/gm creatinine (normo-albuminuria) was 30 subjects and the third group apparently healthy volunteers (diabetes free) was 20 subjects, females were 48 subjects while males were 32 subjects.