الفهرس 
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Abstract
This study aimed to elucidate the effect of caffeine
administration on cerebral cortical activity in preterm infants,
where Amplitude-integrated electroencephalography was used
to monitor cerebral function changes during caffeine
administration, secondary aim was to study the effect of
caffeine administration on preterm infants’
electroencephalographic maturational changes by conventional
and aEEG.
For this purpose the current study was conducted on ٣٣
preterm infants of gestational age less than ٣٤ weeks, at NICU
Ain Shams University during the period between January ٢٠١٢
and July ٢٠١٣.
The studied neonates were randomly divided into
two groups:
group ١ (cases): preterm infants scheduled to
receive a first dose of caffeine for prophylaxis or
treatment of apnea.
group ٢ (control): preterm infants for whom
caffeine was not given.All newborns included were subjected to the
following:
Maternal history taking, Detailed antenatal and perinatal
history, Clinical examination including (gestational age
assessment using Ballard score, Apgar score estimation at ١ &
٥ minute and Anthropometric measures) and Laboratory
investigations (CBC and CRP).
All newborns included in group ١ were subjected to
monitoring before and after caffeine administration including:
cardiovascular monitoring (heart rate, capillary perfusion time,
mean arterial pressure), respiratory monitoring (apnea, capillary
oxygen saturation), neurological monitoring (muscle tone,
arousability).
AEEG(cerebral function monitor) for ١ hour before,
during and ١ hour after administration of a loading dose of
caffeine (٢٠mg/kg body weight), follow up conventional and
aEEG for ١ hour at ٣٦ weeks of post-conceptional age to assess
maturational changes in EEG.
All newborns included in group ٢ were subjected to
conventional EEG and aEEG for ١ hour at ٣٦ weeks of postconceptional
age to compare maturity with conventional and
aEEG at the same age of group ١.The results of our study showed that: there was no
statistically significant difference in CRT, apnea and tone
before and after caffeine administration, there was statistically
significant increase in HR, mean blood arterial pressure,
capillary oxygen saturation and arousability half an hour after
caffeine, there was statistically significant increase in aEEG
continuity (cerebral cortical activity) detected after caffeine
administration compared to before, there was no statistically
significant difference in electrographic seizures activity before
and after caffeine administration.
Cases and control were gestational age, birth weight,
maternal age, weight, OFC, length, sex, mode of delivery
matched, there was statistically non significant difference in
APGAR score at ١ and ٥ minutes, gravidity and cause of
prematurity between cases at ٣٦ weeks and controls,
statistically non significant difference in CBC, CRP, mode of
ventilation and outcome between cases at ٣٦ weeks and
controls.
Statistically significant shorter length of stay detected
among cases compared to controls, there was statistically non
significant difference in electrographic seizures activity and
conventional EEG grade between cases at ٣٦ weeks and
controls, statistically significant higher aEEG score (indicating
better maturation) was detected in cases, compared to controls.