الفهرس 
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Abstract
Stroke is regarded as a severe disorder with high morbidity and high mortality, which is a major healthcare problem and a serious economic burden worldwide. It claims over 6 million deaths each year worldwide (Abd-Allah and Moustafa, 2014).
The CYP2J2 gene is a member of cytochrome P450 (CYP) superfamily, spans ∼40.3 kb on human chromosome 1, band p31.3–p31.2 (King et al., 2002). The epoxygenation of arachidonic acid (AA) by CYP2J2 is efficient and generates epoxyeicosatrienoic acids (EETs) (Capdevila et al., 2007).
Epoxyeicosatrienoic acids has a series of positive effects, such as dilating blood vessels, anti-inflammatory, antithrombotic, promoting the angiogenesis and the growth of endothelial cells (Polonikov et al., 2007).
To date, some studies have identified that the CYP2J2 -50G>T variant may increase the risk of IS, whereas others have not found an association between variation in CYP2J2 and stroke (Liu et al., 2007).
The present study investigated the frequency of CYP2J2 -50G>T gene polymorphism in patients with acute ischemic stroke and evaluate its association with occurrence of the acute ischemic stroke.
For this purpose, samples were collected from 40 patients diagnosed according to neurological and radiological assessment and 10 age and sex matched apparently healthy controls. All individuals included in this study were subjected to full history taking, thorough general, neurological and radiological assessment. The laboratory investigations included complete blood count, lipid profile, and random blood glucose level. Furthermore CYP2J2-50G>T gene polymorphism was assessed by PCR- RFLP.
Our genetic analysis revealed that among ischemic stroke patients, the most frequent genotype of the CYP2J2-50G>T gene polymorphism was the wild TT genotype (82%) followed by mutant genotype GT (18%). We couldn’t find a significant association between CYP2J2 -50G > T variant and acute stroke among our studied Egyptian patients.