الفهرس 
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Abstract
Background: Several factors are important in determining whether a sedative–analgesic combination is clinically acceptable. The ideal sedative–analgesic combination would provide a stable hemodynamic state, no respiratory depression, a rapid onset and recovery to baseline, and a low incidence of postoperative nausea and vomiting. Also will maintain a patient’s hemodynamic status to as close to the presedation state as possible.
There is a significant interest in ketofol as an agent for procedural sedation and analgesia. A combination of ketamine and propofol can be used that can be mixed in the same syringe or administered independently in two separate syringes. Ketofol can be administered as boluses or as a continuous infusion for longer procedures.
Endoscopic Retrograde Cholangiopancreatography (ERCP) when sedated with propofol, related adverse events (SRAES) includes; hypotension, arrhythmia, oxygen desaturation, unplanned intubation and procedure termination.
Aim : Primary aim of the study was to compare propofol and ketofol as a sedative agent regards induction time and recovery time in adult patients undergoing ERCP.
Secondary aim was to investigate the safety and efficacy of both drugs as regards haemodynamic, respiratory compromise, pain, nausea, vomiting, any psychomimetic effect (Agitation, Irritability…) post procedure patient and endoscopiest satisfaction as well as the total dose of drug consumption.