الفهرس 
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Abstract
Antibioticsare used all over the world for the treatment of diseases. Ceftriaxone is a well-known broad spectrumantibacterial thathas proven its efficacy against many pathogens. On the other hand, ceftriaxone can produce serious adverse effects in humans.A lot of interest is paid to improve new medications to give maximum effects with lesser or no side effects. Antibiotics and drugs were reported to produce ROS inside mammalian cells thus increasing side effects and cell damage so great attention ispaid to the pre and concurrent use of anti-oxidants with antibiotic therapy.
Vitamin C and ginseng are potential anti-oxidantsthat can scavenge the produced free radicals and prevent further production of them, thus inhibiting inflammation and reducing oxidative stress effect on cells.
The present study has been carried out to investigate the protective effect of vitamin C and/or ginseng on the adverse effects of ceftriaxone. The results were confirmed through haematological, biochemical and histopathological changes.
Experimental design:
After two weeks of acclimatization to the laboratory environment, a number of fourty male adult albino rats wererandomly allocated into five equal groups.
Group(1) receivedsaline1 ml/ 0.1 kgb.wt.orallyonce daily for 14 successive days.Group(2) receivedsaline1 ml/ 0.1 kgb.wt.orallyonce daily for the first 7 days followed in the next 7 days by I.P. injection of ceftriaxone(180 mg/kg b.wt.)once daily.Group(3)received anoral dose of vitamin C (100 mg/kg b.wt)once daily for the first 7 days and in the following 7 days;the vitamin C dose was combined with I.P. ceftriaxone (180 mg/kg b.wt.) once daily.Group(4)received oral ginseng (200