الفهرس 
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Abstract
Introduction:Ischemia- reperfusion injury (IRI) in the kidney triggers multifaceted network of plasma cascades including the complement, coagulation, kinins, and fibrinolytic system, which play major role in the reperfusion-triggered inflammatory process.
Aim of the work:The aim of the present study was to investigate changes in blood coagulation parameters immediately after ischemia and after ischemia /reperfusion of the kidney in adult rats of both sexes.
Materials and Methods:The study was carried out on 56 adult albino rats of both sexes weighing 160-220 gm. Rats were randomly allocated into 5 experimental groups as follows: Control rat group (C;n=10).Sham -operated rat group 1 (SH1; n=10)subjected to all the procedures of the I- rat group except for renal ischemia and were sacrificed after 45 minutes. Renal ischemic rat group (I; n=10)subjected to renal ischemia for 45 min, then were sacrificed. Sham-operated rat group 2 (SH2;n=10)subjected to all the procedures of IR – rat group except for renal ischemia and reperfusion and were sacrificed after 1½ hour. Renal ischemic /reperfusion rat group (IR;n=10) subjected to renal ischemia for 45 min, then reperfusion for 45 minutes, then wereimmediately sacrificed. All rats were subjected to estimation of body weight (BW), absolute and relative kidney weights (AKW and RKW), hemoglobin (Hb) and hematocrit (Ht.) values , clotting time, prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT) and serumlevels of urea (Ur.) and creatinine (Cr.).
Results; I- rat group showed insignificantchanges inAKW and RKW, CT, APTT, PTand TT compared to SH1 and C-rat groups. However they showed significant elevation in Hb content, Ht. value andserum levels ofUr. and Cr. compared to C rat group. IR rat group showed significant increase in AKW and RKW compared to SH2, I and C rat groups. Also they showed significant increase in Hb. content, Ht. value and serum levels of Ur. and Cr. compared to C- rat group. However they showed no significant change in their CT, APTT, PT and TT compared to SH2, I and C- rat groups
Conclusion; Coagulation parameters are not changed immediately after kidney ischemic / reperfusion and may not contribute to the immediate pathophysiological changes of ischemic reperfusion injury.