الفهرس 
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Abstract
Foot-and-mouth disease(FMD) is ahighly contagious viral disease that affect both domesticated and wild cloven-hoofed animals. FMD has taken an enzootic form in Egypt. So It was necessary to make many studies about how to control this dangerous disease by vaccination using imported or locally produced vaccine.Despite years of biannual vaccination of cattle against foot-and-mouth disease (FMD) using trivalent locally prepared and imported vaccine, the disease still uncontrolled in Egypt. There is no strategic plan for immunization against the disease using local or imported FMD vaccines. At how old are the newborn calves vaccinated and after how many weeks are they revaccinated? Is vaccination every four months or six months in both dairy cows or herds of fattening calves recommended?
In order to answer these questions, the experiments of this thesis were designed to evaluate the immune response of the imported vaccine in a farm in Suez governorate and comparing with Giza governorate farm in which the locally produced vaccine is used to test the serological equivalence of viruses used in the vaccine.And to evaluate the immune response of the imported vaccine in a farm in Gharbia governorate. The Gold standard serum neutralization test was used to evaluate the immune response of each serum samples collected from each farm.
Ten percent of serum samples of animals in each farm were collected pre and post vaccination at different periods except Garbia farm which serum samples collected once.
Results obtained indicates that local produced vaccine showed better immune response against serotypes A,O,and SAT2 than the imported vaccine. However, other immune response tests should be carried out on farms representing East Delta, Central Delta, West Delta, North and South Upper Egypt, to exclude the results of cattle that may have been infected with a field infection and have no satisfactory symptoms.