الفهرس 
INTRODUCTION & Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
HCV is highly prevalent in Egypt. This study aims at addressing the question of mother to infant transmission of HCV. This study was a prospective case- control study done on 425 healthy pregnant ladies in labour whose age range from (17-46 years) who were attending the gynecology and obestric hospital Ain Shams University and Nasr City Health Insurance Hospital.
Sera from 425 health mothers were collected at delivery and
tested for HCV-antibodies by 2nd-generation ELISA and positive reactions were confrrmed by RIBA.2, HCV-RNA for
40 HCV-Ab +ve and 66 HCV-Ab -ve mothers.
Qualitative by RT-PCR, quantitative by Taq-Man-PCR, Genotype by sequence analysis. Also, sera were obtained from 25 babies ofHCV-RNA +ve mothers and (12 babies) of HCV - RNA -ve mothers at birth and for 21 of these babies at 6 months and 12 month they are all tested for HCV-Ab and HCV-RNA at birth, 6m. and 12m. Out of 425 mothers
44 ladies were HCV-Ab +ve (10.4%}, 38/40 (95%) of HCV
Ab +ve ladies had detectable HCV- RNA, 31/35 (88.57%)
had genotype 4a.
HCV-Ab was positive in at birth 42/44 (95.4%) at 6 month
10/21 (47.6%), at 12m 12/21 (57.1%).
HCV-RNA was detected in at birth 4/25 (16%), at 6m. 5/21 (23.8%), at 12m. 6/21 (28.6%).
HCV-Ab and HCV-RNA were -ve at birth, 6m. 12m. for all
babies of HCV-RNA -ve mothers.
Maternal age, parity, mode of delivery, history of blood transfusion and viral load as well as infant’s sex, birth weight, circumcision and type of feeding when taken singly had no significant effect on transmission. Thus there is high rate of mothers to infant transmission of HCV in Egypt.