الفهرس 
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Abstract
Delayed puberty is considered when the boy reaches 14 years old and didn’t start pubertal manifestation or 18 years without it’s completion. This delay may be pathological as in cases of hypogonadotrophic and hypergonadotrophic hypogonadism or constitutional delay (CDP). The latter is the most common type of pubertal delay.
Constitutional delayed puberty is considered as the delay of normal, as the boy enters puberty spontaneously but delayed < 2 years of it’s normal onset and complete it before the age of 18 years, without any significant permanent effect on his sexual or reproductive functions.
The exact etiopathology of CDP is still unclear and many speculations exist in this regard as; genetic factors, nutrition or environmental causes. etc.
Melatonin received much attention from the researchers in the last decades and apart from being inducer of sleep, many other vital functions were discovered. One of these is the regulation of the hypothalamo-pituitary-gonadal axis. It was proved that; its elevation causes inhibition of the whole axis. It’s exact role in CDP is unclear and very few researches exist.
So, we aimed by this work to spot light on it’s relation to CDP through measuring it’s level and to find out its correlation to testosterone, FSH and prolactin in such boys.
The study was carried out on 25 boys with CDP (Tanner’s stages I, II & III) as the patient group and another similar number of age matched, full pubertal boys (Tanner’s stage V) as a control group.
For all; after thorough history and clinical examination, total testosterone, FSH, prolactin and melatonin were measured.
The results were statistically analyzed and showed that:
1. No significant differences between chronological and bone age of the control group, while in CDP group; bone age is significantly delayed compared to their chronological age as well as the bone age of the control group.
2. Weight and height are significantly less in CDP group than that of the control.
3. Serum testosterone is significantly lower in CDP, compared to control group.
4. Serum FSH as well is significantly less than that of the control group.
5. Serum prolactin in both groups showed no significant differences.
6. Serum melatonin is much significantly higher in CDP group, compared to the control.
7. Melatonin is inversely correlated to both testosterone & FSH and have no relation with prolactin.