الفهرس 
Part I: General introductionOnly 14 pages are availabe for public view
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Abstract
In this thesis, lisinopril, enalapril maleate and ramipril have been determined using different spectrophotometric and spectrofluorimetric method. It consists of three parts:
Part I: it provides a general introduction about the investigated compounds such as, pharmaceutical importance, chemical structure and review for the analytical techniques and finally the objective of the suggested work.
Part II: Spectrofluorimetric methods of analysis: it consists of 3 chapters.
Chapter 1: selective spectrofluorimetric method for determination of lisinopril in pharmaceutical preparations and in presence of hydrochlorothiazide: : it is devoted to the development of a novel sensitive and cost effective spectrofluorimetric method for determination of lisinopril in its pure form and pharmaceutical preparations. The method is based on the reaction of the drug with ninhydrin and phenylacetaldehyde in buffered medium (pH 7.0) to form a highly fluorescent product measured at 460 nm after excitation at 390 nm.
Chapter 2: An innovative validated spectrofluorimetric method for determination of lisinopril in presence of hydrochlorothiazide; Application to content uniformity testing: it describes a sensitive and discriminating spectrofluorimetric method for the determination of lisinopril in bulk form and pharmaceutical tablets. The reaction of lisinopril with ethylacetoacetate and formaldehyde in acidic buffered medium (pH 3.8) has yielded a pale yellow product that exhibited a high fluorescence measured at 438 nm after excitation at 350 nm.
Chapter 3: Switch on fluorescence probe for the selective determination of lisinopril in pharmaceutical formulations: Application to content uniformity testing: A switch on fluorescence reaction of fluorescamine as a result of its interaction with the primary amino group of the drug in the presence of aqueous borate buffer (pH 9.5). The fluorescence emission was measured at 475 nm after excitation at 390 nm.
Part III: Spectrophotometric methods of analysis: it consists of 3 chapters
Chapter 1: Simultaneous spectrophotometric determination of binary mixture of enalapril maleate and hydrochlorothiazide in pure form and in pharmaceutical preparations :it is concerned with development of two new, sensitive, simple and economic spectrophotometric methods for simultaneous determination of enalapril maleate and hydrochlorothiazide. The first method, isosbestic point method, was performed by measuring the absolute value of the zero order spectra at 211 nm (intersection point) for enalapril maleate and at 270 nm for hydrochlorothiazide. The second method, ratio subtraction method, is based on spectral isolation of enalapril maleate.
Chapter 2: Two smart spectrophotometric methods for simultaneous determination of lisinopril and hydrochlorothiazide in binary mixtures: Two new, simple, fast and sensitive spectrophotometric methods were developed for analysis of binary mixtures of lisinopril and hydrochlorothiazide. These methods were absorpitivity factor method and ratio subtraction method.
Chapter 3: A novel spectrophotometric method for analysis of binary mixtures of some antihypertensive medications : it illustrates ratio subtraction spectrophotometric method as a tool for the simultaneous determination of two antihypertensive binary mixtures (ramipril/ felodipine and ramipril/ hydrochlorothiazide).
The thesis includes a list of 215 references, it comprises 43 tables and 39 figures, as well as summary in english and in arabic.