الفهرس | Only 14 pages are availabe for public view |
Abstract This thesis was carried out to determine the effect of vitamin C supplementation on serum uric acid concentration. It was a prospective double blinded study included 40 patients (23 males-17 females) with asymptomatic hyperuricemia aged between 48 and 77 years old. All patients were subjected to history taking, clinical examination and lab Investigations. The patients were randomly assigned into two equal groups: group I: twenty patients that were instructed to go on a low purine diet and received allopurinol 300mg/d and vitamin C Supplements 500mg/day for 2 months. group II: twenty patients that were instructed to go on a low purine diet and received allopurinol 300mg/d and placebo for 2 months Serum uric acid level was measured for all patients at the beginning and at the end of the 2 months. Results showed the following findings: There was no significant difference between the two groups as regards demographic and laboratory data The percentage of hyperuricemia was higher in males than females. There were statistically significant positive correlations between baseline SUA and age, BMI, lipid profile including (cholesterol, triglyceride, LDL), fasting and post prandial blood glucose and systolic and diastolic blood pressure and significant negative correlation with HDL. There were positive correlations between SUA and serum creatinine. In a multivariate variable study we found that LDL and cholesterol had a significant independent risk on the level of serum uric acid. As regard serum uric acid it significantly decreased in two groups with percent of change in group I was about 24.66 % ± 4.3 and in groups II 16.9% ± 3.8 and there was a significant DROP difference between the two groups with percent of DROP in SUA in group one about 50% more than group two. |