الفهرس 
Cardiac Arrest and Post Cardiac Arrest SyndromeOnly 14 pages are availabe for public view
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Abstract
Cardiac arrest is one of the greatest medical emergencies. Successful resuscitation is associated with development of post cardiac arrest syndrome. Post cardiac arrest patients have high risk of mortality and morbidity.
Brain injury plays an important role in determining patients’ outcome in post cardiac arrest patients. Serum brain specific markers levels (e.g Neuron-specific enolase, Serum-100B) and Electroencephalogram could indicate the extent of brain injury and help predict outcome .
Aim of the Work:
To study the levels of Neuron-specific enolase , Serum-100B and Electroencephalogarm patterns in post cardiac arrest pediatric patients and to correlate these findings with cardiac arrest circumstances and patients’ outcome.
Patients and methods:
This prospective observational study was conducted in the period from January 2017 to March 2018 in Pediatric Intensive Care Unit, Children ’s Hospital, Ain Shams University, Cairo, Egypt.It included 41 post cardiac arrest patients who underwent serum sampling for Neuron specific enolase, Serum 100B and Electroencephalogram
Results:
24 patients (58.5%) were males .Patients’ ages ranged from 3 months to 12 years. Our study results showed that 8 out of 41 (19.5%) pediatric patients survived to hospital discharge.Infants were less likely to survive to hospital discharge (13%) compared to young children (27.27%) and old children (28.57%).
Convulsions were common feature in our patients seen in 8 out of 41 patients (21.9%(
Mortality was higher in patients with convulsions. None of patients with convulsions survived in our study compared to 25% survival in patients with no convulsions.
Regarding sepsis, 34 patients out of 41 patients (82.9%) had sepsis, sepsis was associated with higher mortality where only 5 out of 34 patients with sepsis (14.7%) survived to hospital discharge. compared to 4 out of 7 non-septic patients (57.14%)
Median NSE was higher in patients who died within 5 days(12.55 ng/ml) after cardiac arrest less in those who died after more than 5 days (6.7 ng/ml)and least in those who survived (5.31 ng/ml).
Also NSE median was higher in overall patients who died (9.25 ng/ml) compared to those who survived (5.71 ng/ml)
Neuron-specific enolase Level was positively correlated with duration of arrest
Median Serum 100B was higher in patients who survived less than 5 days (0.3 ng/ml) compared to those who survived more than 5 days (0.2 ng/ml).
Regarding EEG,All patients with burst suppression died within 5 days.
50% of patients with suppressed background died within 5 days and 25% died after 5 days (75% overall mortality)
The highest survival rate (77.8%) was in patients with no epileptogenic activity
Key words : cardiac arrest , post-resuscitation , outcome , Neuron-specific enolase, Serum100B, Electroencephalogram .