الفهرس 
Introduction & Aim of the WorkOnly 14 pages are availabe for public view
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Abstract
Introduction: Cancer patients have a high risk of infections due to immunosuppression , chemotherapy, radiotherapy and steroid therapy. This lead to increase using of antibiotics and increasing their resistance. Aim of the Work: The aim is to determine the frequency of gram negative bacteria causing infections, pattern of antimicrobial susceptibility of the isolates and frequency of carbapenems resistant gram negative isolates In cancer patients in Mansoura Oncology Center by using the phenotypic methods. Reserch plan: This study includes 40 cancer patients in Mansoura Oncology Center suffering from various infections from April 2016 to September 2016. Different samples were collected according to site of infections. Identification of organisms was done Pheynotypically using conventional methods and automated vitek 2 system. Also, Antimicrobial susceptibility testing was done by disk diffusion method and by automated Vitek 2 system. Result: Among of 663 samples during the study, 40 isolates (15.7%) were carbapenem resistant. K.pneumoniae (22) followed by E.coli (4) were the most common causes of bacterial infections in cancer patients in our study. Tigecycline and colistin were the most sensitive antibiotics for carbapenem resistant isolates. Discussion: carbapenem resistant gram negative bacilli are a major problem in cancer patients. Tigecycline and colistin are a good treatment for them. Conclusion: Cancer patients have a high risk of infections. K.pneumoniae and E.coli were the most common causes of bacterial infections in cancer patients. Tigecycline and colistin were the most sensitive antibiotics for carbapenem resistant gram negative bacilli.