الفهرس 
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Abstract
Clostridium perfringens type A has a great impact in rabbit farms due to great loses and high mortalities specially among weaned rabbits, it causes severe diarrhea, bloat and enterotoxaemia. In the present work, C. perfringens alpha toxoid vaccine adjuvanted by either aluminum hydroxide gel and poly lactide co-Glycolic acid (PLGA) nanoparticles was prepared. It was revealed that enterotoxaemia and bloat vaccine adjuvanted by aluminum hydroxide gel in 2 doses protect rabbits for 6 months, while the vaccine adjuvanted by PLGA nanoparticles protect rabbits for 10 months after one shot of administration.