الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Background: The aim of this study was to investigate whether systemic vascular resistance (SVR) correlates with validated prospective scoring systems such as Model for End-stage Liver Disease (MELD) and its modification MELD Sodium.
Methods : Patients with cirrhosis, who were admitted to hospital with decompensation (as defined by development of ascites, hepatic encephalopathy, and variceal bleeding) with and without renal failure and underwent echocardiography were included in this study.Compensated cirrhosis patients were also included. Laboratory data required for computing MELD score, serum bilirubin, serum creatinine, international normalized ratio, and serum sodium were collected for every patient. We tabulated hemodynamic and echocardiography parameters that enabled calculation of SVR. We analyzed the correlation between SVR and each of the individual prognostic scores.
Results : A total of 60 patients with a diagnosis of decompensated cirrhosis were included in the study in which 30 have renal failure. 30 patients were found to have a low sodium level (<135 mEq/L) and 30 were found to have a normal sodium level (>135 mEq/L). In the patients with hyponatremia, we found statistically significant inverse correlations between SVR and validated liver severity models. However, these correlations were not seen in patients with normonatremia.
CONCLUSION: We observed a statistically significant inverse correlation between SVR and all the validated liver disease severity models used in this study among patients with hyponatremia but not in those with normonatremia.