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Abstract The Aim of radiotherapy is homogeneous dose in the target volume (Tumour) and Optimal sparing of the surrounding normal tissues. The daily set-up errors are the major problem that face the patient during the treatment. The uncertainties in the daily set-up of the Prostate cancer patients during the treatment can give rise to the complications the results of the treatment. Those Set-up errors (uncertainties) can be reduced by repositioning of the patient according to the setup verification. According to this, protocol for repositioning of the patients is chosen. on which re positioning that yields the lowest radiation dose to the organs at risk (OAR), and thereby less side effects to patients. The purpose of this work was the determination of the set-up errors for Prostate cancer patients and investigation of the dose distribution and dose-volume variations of planning target volume (PTV) and organ at risks (OARs). The electronic portal imaging device (EPID) is used as tool to verify the patient treatment positioning. This could be done by the means of identifying and correcting the field displacements in patient’s setups which requires accurate patient positioning with reference to the initial three-dimension conformal Abstract iii radiotherapy (3DCRT). Patient setup is controlled by comparing the Digitally reconstructed radiographs (DRR) with portal images acquired immediately before patient treatment. It is generally accepted that two classes of set-up uncertainties identified by Σ setup and Random setup errors σ setup. A study on 15th prostate cancer patients using Varian Linear accelerator model DMX to treat and portal image device Si500 shall be used to evaluate the selected portal images taken for each patient. In this study comparison has been made between previous publish work and new approach. The margins which are calculated according to ICRU Report 62 that is suggested as an optimum margin for target volume coverage which is <3 mm in all three directions. And indicate the effect of set-up errors on the dose distribution and dose volume histogram (DVH) has been determined by calculating the dose distribution and dose volume histogram (DVH) of PTV and OARs of actual treatment plan and treatment plan with setup errors correction. |