الفهرس 
Coordination ChemistryOnly 14 pages are availabe for public view
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Abstract
The ligand, 2-(phenylamino)acetohydrazide (HL) was prepared and characterized. The ligand reacted with Cu(II), Ni(II), Co(II) ,Mn(II), Zn(II), Cr(III) and Fe(III) ions to yield complexes of metal to ligand molar ratio 1:1,1:2 and 2:1. The obtained metal complexes have been characterized using elemental, spectral (IR, UV- Vis) and thermal analyses (TGA), as well as magnetic moment and molar conductance measurements. The ligand in the obtained solid complexes coordinates as a bi-dentate either as a neutral via the amino group nitrogen and carbonyl oxygen atoms or anilino NH or as a monobasic via the amino group nitrogen atom and enolic (C-O) oxygen atom in the enolimine-tautomeric form. The possible antifibrotic activities and histopathological examination of Cu (II) complexes were estimated as well as their effect on liver function and caspase -3 expressions were assayed. Results revealed that administration of Cu (II) complexes to the CCl4-intoxicated mice led to improvement in the hepatic function as well as liver histology. Moreover, treatment with these complexes led to a marked decline in the caspase-3 expression in hepatic cells.