الفهرس 
Prolactin (PRL)hormone
Sites of synthesis and secretion of PRLOnly 14 pages are availabe for public view
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Abstract
Prolactin (PRL) is a polypeptide hormone that is synthesized in and secreted mainly from lactotrophs of the anterior pituitary gland. PRL does not only subserve multiple roles in reproduction other than lactation, but it also plays multiple homeostatic roles in the organism.Furthermore, the synthesis and secretion of PRL is not restricted to the anterior pituitary gland, but other organs and tissues in the body have this capability. Hyperprolactinemia (HPRL) is a disorder of prolactin secretion in which the concentration of prolactin in blood very high. It can be caused by drugs such as drugs treat nausea and gastric ulcers. Hypersecretion of prolactin can cause many problems such as hypogonadism, infertility and loss of libido in adult males. The present work is planned to evaluate the effects of HPRL induced by metoclopramide (MCP) on fertility of adult male rats.Physiological changes of PRL, LH, FSH, testosterone hormones and acid phosphatase enzyme, in addition to histological and immunohistochemical changes of testes of adult male rats were studied. The rats were divided into four equal groups (10 rats / each group). group I, normal control rats that were injected with saline solution i.p.daily for 10 weeks. Groups II, III and IV, the rat were treated with MCP i.p. in a dose of 2.2 mg/kg/ b.w daily for different durations as 4, 7 and 10 weeks, respectively.