الفهرس | Only 14 pages are availabe for public view |
Abstract Over the past decade illness outbreaks have posed a serious threat to human life and well-being. The 2009 outbreak H1N1/A influenza virus also was expected to disproportionately affect healthy young persons under the age of 25 years. The present study aimed to investigate the liver function, oxidative stress, monoamines alternation and immunological response induced post injection of H1N1 vaccine and its ingredients on male albino mice. The present study showed that the injection of thiomerosal, adjuvant, H1N1 antigen and H1N1 vaccine were caused significant decrease in AST, ALT and ALP levels which may be due to the leakage of these enzymes from the liver cytosol into the blood stream. Also, they caused significant increases in oxidative markers namely lipid peroxidation and nitric oxide. This induction of oxidation was extent to cause a significant decrease in glutathione level on the brain. This alternation was associated with a significant decrease in norepsinephrine (NE) and dopamine (DA) contents of hypothalamus. |