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Abstract In this study we aim to compare the estimated KRU from the equation using serum pre-dialysis BTP with actual KRU measured using serum urea and urinary urea in ESKD patients on regular HD who retain RKF. We divided the patients into 2 groups. Group1(G-1)had urine output >500ml/24 hrs and group2(G-2) had urine output 200-500 ml/24 hrs. Strong correlation between estimated and measured KRU in G-1 with correlation coefficient of r=0.741 which is highly significant at p<0.001. In G-2 the correlation was week at r-0.462 and significant at p<0.05. Mean bias between estimated and measured KRU was 0.7 mL/min with 95% limits of agreement between 3.5mL/min and -1.96mL/min in G-1. In G-2 the mean bias was -0.54mL/min with 95% limits of agreement between 0.75mL/min and -2 mL/min. Comparing the estimated KRU in the 2 groups showed t value of 3.06 at p<0.01. Comparing the measured KRU in 2 groups showed t-value is 4.5 at p<0.01. There is a highly significant difference between the estimated and measured KRU in two groups. In conclusion, serum BTP can be used to estimate RKF and RKU without urine collection. However the estimation may become better in patients with urine output more than 500ml/24 hrs than those with urine output 200-500 mL/24 hrs. |