الفهرس 
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Abstract
There is growing evidence that the lack of vitamin D sufficiency may be involved in a variety of systemic diseases, many of which manifest later in life.
In several studies, the relation between low vitamin D levels, insulin resistance and impaired insulin secretion was clearly demonstrated. Moreover, specific receptors for 1,25(OH)2D3 were detected in pancreatic ß cells, denoting a probable effect of vitamin D on the insulin secretion process.
The aim of the present study was to determine the relation between vitamin D concentration, triglycerides, HDL and cholesterol in early pregnancy and risk of GDM.
This study was carried on 120 pregnant women we measure 25[OH]D3 concentration, TG, HDL, cholesterol in early pregnancy (11-14) weeks, the selected cases were classified later at (24-30) weeks of gestation according to the results of GCT into 2 groups respectively.
Group1 (study group) Included 28 pregnant females complicated at this pregnancy with GDM that confirmed by GCT, Group2(control group) Included92 healthy pregnant females with normal GCT. we found that 25[OH]D3 concentrations (11.0-14.0) ng/ml in Group1(study group) compared to (13.60 – 36.70) ng\ml in Group2(control group) with Mean ± SD. (13.11 ± 0.88) and Median13.0ng\ml in Group1(study group) compared to (23.58 ± 6.08) and Median 22.10 ng\ml in Group2(control group).
The pregnant women with vitamin deficiency≤14.0 ng\ml have 3.3 fold higher risk for GDM .
In this study Group1(study group) who developed GDM had higher levels of TG vs non GDM cases (101.0 – 290.0) vs (40.0 – 200.0), and Mean ± SD in cases who developed GDM vs non GDM cases (235.04 ± 40.45) vs (96.45 ± 33.14) and Median 238mg\dl in Group1(study group) compared to Median 90 mg\dl in Group2(control group). high levels of TG in early pregnancy (cut off point>155mg\dl) increase the risk of GDM 3.3 fold higher than others.