الفهرس 
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Abstract
Atherosclerotic cardiovascular disease, a chronic inflammatory disease considered as the leading cause of death worldwide. MicroRNAs have been shown
to be associated with physiological and pathological conditions as inflammation
and cardiovascular disease. On the basis of the communication among
microRNAs, inflammation, and atherosclerosis, we hypothesized that
inflammation-related miRNAs, miRNA-155, could play a role in the progress of
atherosclerosis.
In the present study, we aimed to determine the levels of circulating
miRNA-155 in patients with chronic stable angina and to study the impact of
miRNA-155 on the severity and extent of coronary artery disease. MicroRNA was
extracted and assessed from plasma of 50 subjects (20 controls and 30 patients
with chronic stable angina) using quantitative reverse-transcription PCR (RTPCR).
Levels were compared in the two groups and correlated with Gensini score
in the group with chronic stable angina (CSA).
We found that, Plasma levels of miRNA-155 were significantly lower in
CSA patients (0.59±0.48, 1.94±0.76, in patients and control group respectively.
P<0.001). The expression of miRNA-155 correlated negatively with Gensini scores
(P<0.001), total cholesterol (P <0.001), LDLc (P= 0.002) and triglycerides (P= 0.03). There was a significant difference in miRNA-155 levels among the quartiles
of the CSA group (P < 0.001) indicating an inverse correlation between miRNA-
155 and the extent of coronary artery disease. ROC curve showed that miRNA-155
sensitivity and specificity for the prediction of severity of atherosclerosis were
86.67% and 80% respectively.