الفهرس 
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Abstract
Pyranoquinolinediones were synthesized and subjected to nitration followed by reduction to produce a novel 3-aminopyrano[3,2-c]quinoline-2,5- diones. Structure of compound 3c has been investigated and confirmed by 2D – NMR (gCOSY, gHSQC and gHMBC). Anti-oxidant and anti-cancer activity with molecular docking of 3-aminopyranoquinolinones has been evaluated. 3-amino-N- butyl-pyranoquinoline-2,5-diones precursor was utilized to obtain some novel heteroannulated pyrano[3,2-c]quinolone derivatives. These heteroannulation reactions afforded novel heterocyclic systems fused to pyranoquinolinone at face c, such as oxazole, triazine and pyrazine. A series of interesting Schiff bases and azo dyes derivatives of pyranoquinolinone were synthesized.
Keywords: Quinolinone, Pyranoquinolinone, Molecular docking, Heteroannulated tetracyclic systems, Oxazolo, antioxidant, anticancer, Spectral analysis.
Supervisors:
Prof. Dr. Mustafa Mohamed Ismail
Professor of Organic chemistry, Department of chemistry, Faculty of
Education, Ain shams University
Prof. Dr. Alaa Alden Salem
Professor of analytical chemistry, Department of chemistry, Faculty of
Faculty of Science – UAEU
Asst.Dr. Hany Mohamed Hassanin
Assistant Professor of Organic chemistry, Department of chemistry, Faculty of Education, Ain shams University
Asst.Dr. Ibram Mahmoud Abdou
Associate Professor of Organic chemistry, Department of chemistry, Faculty of Faculty of Science – UAEU