الفهرس 
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Abstract
Recently, conventional administration of drugs have been replaced by modified or controlled-release drug delivery systems in order to provide a constant supply of the drug at a controlled rate over an extended period of time. Therefore, sustained-release (SR) dosage forms are considered to be effective in reducing drug’s dosing frequency with improved patient compliance and reduced side effects. Such SR property can be achieved by formulating the drug into a polymeric matrix which can slowly release the drug at the site of absorption after oral, buccal or transdermal administration.
Matrix tablets are oral dosage forms, widely used for SR purposes due to ease of fabrication with simple formulation procedures and low manufacturing cost. They can control the rate of drug release depending on the type of matrix polymers.
Additionally, transdermal drug delivery systems have been extensively studied as an alternative route for controlled drug release, since they have several important advantages over other traditional dosage forms. They can offer a sustained permeation of the drug across skin and allow for more consistent serum drug levels which is often the goal of therapy with more patient compliance.
Certain antidepressant drugs such as venlafaxine hydrochloride (VFH) possesses a short half-life and a decreased bioavailability requiring frequent administration to get the desired therapeutic activity. It represents a good candidate for formulation into SR dosage forms. Therefore, the aim of this thesis was to formulate once daily SR dosage forms of VFH such as oral matrix tablets and transdermal patches.