الفهرس 
TRANSLOCATION (8;21) ACUTE MYELOIDOnly 14 pages are availabe for public view
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Abstract
Translocation (8;21) is the most frequent chromosomal aberration in adult de novo AML. The t (8;21) involves acute myeloid gene 1 (AML1) of chromosome 21 and myeloid transforming gene 8 (ETO) of chromosome 8 and it gives rise to AML1–ETO positive AML. The promotion effect of the fusion protein AML1-ETO on the growth arrest and apoptosis of hematopoietic cell progenitors suggests that cooperating mutations must overcome this cell death in order for leukemia to develop. The t(8;21) is often detected together with additional cytogenetic and molecular abnormalities. The most common cytogenetic aberrations are loss of sex chromosome followed by deletion of the long arm of chromosome 9 and trisomy 8. However, previous studies showed conflicting data regarding the role of secondary cytogenetic aberrations in addition to t(8;21).
This study aimed to investigate the effect of additional aberrations (loss of X chromosome and del (9q)) on the clinicopathological and prognostic behavior of t(8;21) de novo AML patients.
Keywords: chromosome 9; Trisomy 8