الفهرس 
Pre-eclampsiaOnly 14 pages are availabe for public view
 |  | from | 172 |  |  |
| | | from | 172 | | |
Abstract
Background: Pre-eclampsia is a multisystem complication that occurs after 20 weeks of pregnancy and can cause considerable maternal and fetal morbidity and mortality. This complex condition is characterized by suboptimal uteroplacental perfusion associated with a maternal inflammatory response and maternal vascular endothelial dysfunction. One of the main reasons for serial clinical assessment in antenatal care is the early detection of signs indicative of evolving preeclampsia. Aim: This study aim to assess the accuracy of maternal serum omentin-1 level during the first trimester as predictor for development or occurrence of preeclampsia. Omentin has been shown to act as an anti-inflammatory mediator and in one study has been shown to inhibit TNF-induced vascular inflammation in human endothelial cells. In another report, omentin also inhibited TNF-a-induced vascular cell adhesion molecule-1 expression by preventing the activation of p38 and JNK at least in part through the inhibition of superoxide production. In our study, there were no statistically significant differences between early &late onset PE as regard maternal age, BMI & women with early onset PE delivered at earlier GA and had higher SBP, DBP and meanarterial blood pressure and had low birth weight, SGA and a higher 24-h urinary protein compared with late onset PE. There was significant negative correlation in preeclamptic women between omentin level and both mean arterial blood pressure & 24-h urinary protein. Conclusion: from this study it was concluded that women who developed PE had lower serum omentin levels than women who did not develop PE with a sensitivity of 80.5% and specificity 80.5% and that the degree of decline is highly associated with severity of the PE with sensitivity 88.2% and specificity 100%.