الفهرس 
Mechanical ventilationOnly 14 pages are availabe for public view
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Abstract
Background
It is a well-known fact that intubation and mechanical ventilation have some very important potential risks in addition to obvious benefits. Ventilator associated pneumonia and ventilator-associated lung injury (VALI) are the most serious complications.
Patients and Methods
In this prospective observational study, one hundred and forty-seven mechanically ventilated patients were recruited from Pulmonary ICUs in Ain shams university between July 2015 and February 2016. Only one hundred and twenty patients met the inclusion criteria (mechanically ventilated ≥ 48 hours). We reviewed their medical records and data for factors related to the occurrence of ventilator associated lung injuries were collected after 48 hours of mechanical ventilation.
Results
In this prospective observational study, out of 147 patients were mechanically ventilated, 120 patients met the inclusion criteria (were mechanically ventilated> 48 hours). 66 patients were males (55 %) and 54 were females (45 %). The weight of the studied cases ranged from 40 to 140 Kg , with the mean weight was 90.37. There was a strong correlation between weight and development of VALI (P value = 0.0006). The study showed no correlation between smoking and development of VALI in the current study. The duration of MV of the studied cases ranged from 2 to 94 days. The duration was higher in VALI group (mean 18.73 days) in comparison to their peers (mean 10.07) and this was statically significant (p value = 0.008). The main complications of mechanical ventilation in the studied cases were VALI, VAP and ARDS. Thirty-four patients (28.3%) had VAP, making it the most common complication. VALI came next with 15 patients (12.5%), while, ARDS came in the third place with only 5 patients (4.2%).
Conclusion
High plateau Pressure is an important risk factor for development of VALI. The longer the duration of mechanical ventilation, the higher incidence of VALI.