الفهرس 
AbstractOnly 14 pages are availabe for public view
 |  | from | 158 |  |  |
| | | from | 158 | | |
Abstract
Pharmacokinetics and pharmacodynamics of cefquinome were studied in calves after intramuscular injection of cefquinome (2mg/kg B.WT) healthy and diseased calve alone and in combination with flunixin (1mg/ kg BW). Cefquinome was detected in plasma of calves from 5.0 minutes to 24 h. following IM injection. Cefquinome peak concentration Cmax in healthy calves was (0.783 ± 0.088 µg/ml), and with co-administration with flunixin 0.906 ± 0.102 and 0.916 ± 0.037µg/ml, respectively. The Tmax in healthy calves (0.66 ± 0.09 h.) and 0.90 ± 0.10 h. in diseased calves treated with cefquinome alone and 1.05 ± 0.20h diseased calves treated with cefquinome and flunixin. Pharmacokinetic/ Pharmacodynamic modeling after intramuscular administration of cefquinome in diseased calves treated with cefquinome (2 mg/kg B.WT) and with flunixin for 5 days, the clinical parameters showed rapid recovery in all treated groups. from the obtained data it could be concluded that cefquinome act effectively in treatment of bacterial respiratory disease in calves as well as the co-administartion of flunixin with cefquinome showed highly synergistic activity in treatment of bacterial respiratory disease (Pasterella infctions) in suckling cow calves.