الفهرس 
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Abstract
Abstract
The current study was designed to examine the possible beneficial effect of L-carnitine in preventing the acute renal failure and related oxidative stress caused by administration of gentamicin in rats. The study showed the haemato-biochemical effects of L-carnitine were tested against gentamicin induced nephrotoxicity in adult male albino rats. To achieve this purpose, a comparison was occurred between normal control rats group and nephrotoxic rats group, nephrotoxicity was induced in adult male albino rats by injection of gentamicin intraperitoneal at a dose 80 mg/kg b.wt. for 10 days. Intraperitoneal administration of gentamicin led to a significant elevation in the levels of β2-microglobuline, urea, creatinine, globulin, potassium (K), total oxidant status (TOS), oxidative stress index (OSI), monocyte concentration, prothrombin time (PT), activated partial thromboplastin (APTT), fibrinogen, osmotic fragility (%), ferritin , iron (Fe), total iron binding capacity (TIBC) and transferrin. Meanwhile, gentamicin treatment exerted a significant decrease in total protein level, albumin level, sodium (Na) level, total nitric oxide (TNO) level, total antioxidant status (TAS) level, red blood cells (RBCs) count, haemoglobin (Hb) concentration, haematocrit (Hct) level, white blood cells (WBCs) count, granulocyte concentration and platelets count. Nosignificant was observed in the levels of mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), lymphocyte and transferrin saturation as compared to their corresponding normal control rats group. After that nephrotoxic rats were treated intraperitoneal with L-carnitine at low dose (300 mg/kg b.wt.) or high dose (600 mg/kg b.wt.) for 15 and 30 days. As a result of L-carnitine treatment a remarkable correction was occurred in all previous parameters dependent on the dose and time of treatment. The aim of this work was designed to examine the possible beneficial effect of L-carnitine in amelioratting the renal failure and related oxidative stress caused by administration of gentamicin in rats.