الفهرس | Only 14 pages are availabe for public view |
Abstract This study was conducted on 404 patients with chronic hepatitis C virus infection who were randomly selected from the outpatient clinic of Viral Hepatitis Treatment Unite, Beni Suef General Hospital. This study recommended a pretreatment scoring system for Egyptian patients infected with HCV , as a predictor of sustained viral response (SVR) to pegylated interferon plus ribavirin therapy. This study instructed 4 pretreatment scoring systems (166 Patients) , as predictors for SVR Score 1 , contained all variables Score2” Biopsy + RNA + AFP” Score3”RNA + AFP” Score4”AFP alone Then 3 test groups (with the other 238 Patients) were re-evaluated using these scoring systems Test G. 1 Score 4 had the highest Sensitivity100.0%, Score 1 had the highest specificity72.2%, Test G. 2 Score 4 had the highest Sensitivity 88%, Score 2 had the highest specificity 59.62% Test G. 3 Score 4had the highest Sensitivity 94%, Score 1 had the highest specificity 64%. AFP alone had the highest Sensitivity 100%, 88%, 94%, , in all 3 test groups. Score 1 of all variables had the highest specificity in two test groups 64%, 72.2%, while score 2 had the highest specificity in one test group(59,6%) By study of predictors of SVR: Our study showed that patient‘s age, weight, random blood sugar, ALT level, PC%, total bilirubin level, staging of fibrosis on liver biopsy, and AFP level correlated well with SVR rates. On the other hand patient‘s gender, viral load (RNA copies), AST level, H/O of schistosomal infection, grading of activity on liver biopsy and platelets count did not correlate with SVR rates. |