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Abstract
Seventy two Wistar male rats, weighing 250-350 g, were used to evaluate the influence of feed restriction and green tea on the blood parameters in rats with hyperthyroidism or hypothyroidism. For this purpose rats were reared for 6 weeks then divided into 9 groups, the 1st served as control group (C), the 2nd was feed restricted group (F), the 3rd was green tea extract administrated group (G), the 4th was hypothyroid induced group (Ho), the 5th was hypothyroid feed restricted group (HoF), the 6th was hypothyroid green tea extract group (HoG), the 7th was hyperthyroid induced group (Hr), the 8th was hyperthyroid feed restricted group (HrF) and the 9th was hyperthyroid green tea extract group (HrG). Hypothyroidism was induced in rats by administration of 6-n-propyl-2-thiouracil in drinking water to a final concentration of 0·01% for 6 weeks. Hyperthyroidism was induced by administration of thyroxine 200 μg/L in drinking water for 6 weeks. Feed restriction was applied by feeding the rat 60% of the food given to the control group. Green tea was used at a concentration of 0.5% tea aqueous extract in drinking water. GSH, CAT and TAC were decreased in Ho, HoF and Hr groups and were increased, in F and G groups. While, they did not differ than control in HoG, HrF and HrG groups. MDA was increased in Ho, HoF and Hr rats and was decreased, in F and G groups however, it did not differ than control in HoG, HrF and HrG groups. Serum total proteins and globulins concentrations were decreased in Ho and HoF groups and were increased in all hyperthyroid groups. Serum glucose concentration was increased in Hr group and was decreased in F, G, Ho, HoF. Cholesterol and LDL were increased in Ho and HoF groups and they did not differ than control in HoG rats while, they were decreased in the other groups. T3, T4 levels were increased in all hyperthyroid groups and decreased in all hypothyroid groups while, they were increased in HoG in comparison with Ho and HoF groups however, they decreased mildly at 6th week in F and G groups. Testosterone level was increased in Hr rats and were decreased in all hypothyroid groups in addition it was decreased in F and G groups while, it did not differ in HrF and HrG rats. sALT, sAST, urea and creatinine were increased in Ho, HoF and Hr groups and they did not differ in HoG, HrF and HrG groups in comparison to control. It is concluded that Co-administration of green tea with hypothyroidism and hyperthyroidism significantly modulate the adverse effects of them by enhancing the antioxidant status of rats. In addition, feed restriction can overcome the deleterious effects of hyperthyroidism while, it don’t make significant effect in hypothyroidism in rats.