الفهرس | Only 14 pages are availabe for public view |
Abstract Pemphigus vulgaris is an autoimmune blistering disease that affect the skin and mucous membranes. It is mediated by circulating IgG autoanibodies directed against cell-cell adhesion between the keratinocytes and characterized by intra-epithelial bulla on the skin and mucosa. The aim of this work was to evaluate clinically and biochemically the effect of zinc supplement on serum uric acid in pemphigus vulgaris patients under corticosteroid treatment.. In this clinical study, 2o Pemphigus Vulgaris patients will be selected for this study from the patient pool at dental clinic of the Oral and Periodontology department of the faculty of Dentistry , Alexandria university. There were equally divided into 2 groups: Group1 (control group): 10 patients will be given a topical& systemic corticosteroid therapy (conventional therapy). Group 2 (test group): 10 patients will be given topical & systemic corticosteroid & zinc therapy. The results of this present study revealed that chelated zinc supplement in adjunctive to conventional systemic and topical corticosteroid, enhance the healing of the PV oral mucosal lesions and re-epithelization of eroded oral mucosa in comparison to the conventional therapy (topical& systemic corticosteroid).the recommended dose of zinc elevate serum uric acid within normal range after three months of therapy |