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Abstract The Central venous lines (CVLs) are increasingly used. with nurses heavily involved in their management. The aim of this study was to assess the effect of CVL bundle interventions on patient‘s outcome. The study hypotheses were improvement of physicians and nurses‘ level of performance toward application of central venous line bundle interventions. And improvement of patient outcomes. This quasi-experimental study with pre-post assessment was carried out in the cardio-thoracic Intensive Care Units at Ain Shams University Hospital. It involved 50 nurses, 27 physicians and 220 patients. Data collection tools included physicians and nurses’ assessment tools, observation checklist for nurse’s practice, central venous catheter insertion audit tool, patient assessment sheet, and unit policy assessment checklist. The researcher developed and implemented a training program to participants. The results revealed that participants had deficient knowledge of the CVL bundle and related infections, and their performance, whether audited or observed (for nurses) was inadequate. Assessment of the unit policy regarding nosocomial infection control showed deficiency in most structure items, and improved patient’s outcomes. Hence, it is recommended to make sure the availability of human and non human resources to ensure for proper implementation of the bundle components in the hospital. |