الفهرس | Only 14 pages are availabe for public view |
Abstract Congenital heart diseases represent a major global health problem. Increased ROS levels in the cell, resulting from their overwhelming generation or impaired destruction, have a substantial impact on normal cellular function. This imbalance between prooxidant and antioxidant factors, defined as oxidative stress, can affect cellular homeostasis either through direct oxidative damage of basic cellular components or through the activation of various redox-sensitive signaling pathways, leading to defective cellular function, ageing, disease, or apoptosis . |