الفهرس 
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Abstract
both of the Epstein Barr virus (EBV) and cytomegalovirus (CMV) may have an impact on the progression of hepatitis C virus (HCV) chronic liver disease. A comparative cross sectional study was carried out on eighty chronic HCV patients who were divided into three groups according to progress in their clinical condition using ultrasonography of the abdomen and other laboratory investigations: group 1; consisted of twenty chronic HCV hepatitis patients without any apparent complications, group 2; consisted of thirty HCV cirrhotic patients and group 3; consisted of thirty HCV patients with HCC, besides a control healthy
group consisted of twenty individuals. Serological tests were used to evaluate the prevalence of EBV and CMV infections in the four studied groups. ELISA technique was used for detection of antibodies specific for both EBV antigens (VCA-IgG, VCA-IgM, EA-IgG, EA-IgM, and EBNA-IgG) and CMV (CMV-IgG and CMV-IgM), then the serological findings were interpreted to define the exact infection status and determine the viral reactivation among the studied groups. The study concluded that there is not a significant role played by the co-infection between HCV and EBV or CMV in progression of HCV chronic liver disease into cirrhosis and HCC; however, most trends favored more reactivation in the chronic HCV patients with complications.