الفهرس 
Pregestational Diabetes Mellitus Type1 and Type 2Only 14 pages are availabe for public view
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Abstract
Summary
his observational cross-sectional study was carried out at
Ain Shams University Maternity Hospital during the
period from September 2012 till December 2013. Our study
aims at assessing the reliability of random urine sample (urine
Albumin /Creatinine ratio and urine Protein/Creatinine ratio) as
a screening method for assessment of Micro-albuminuria and
proteinuria in diabetic pregnant women.
The current study included pregnant women with
pregestational diabetes mellitus either type 1 or type 2 diabetes
mellitus. Women with chronic renal disease, autoimmune
disease, multiple gestation, gestational diabetes mellitus,
preeclampsia and current or recent urinary tract infection were
excluded. The 24 hour urine sample was collected for protein
and microalbumin estimation. A random urine sample was
taken for checking (microalbumin, protein and creatinine)
levels and the urinary albumin/creatinine ratio, urinary protein/
creatinine ratio was calculated. Blood sample was taken for
measuring blood urea nitrogen and serum creatinine for
excluding renal impairment and measuring HbA1C to detect the
glycemic state of the patient.
A total 100 pregnant women were included. All included
women had pregestational diabetes mellitus with age ranged from
18 years to 35 years with mean ±SD 30.2±4years and gestational
age from6 weeks to 36weeks with mean±SD26.8±9weeks. Of the
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Summary
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included 100 women, (56%) 56 women had no microalbuminuria,
(38%)38 women had microalbuminuria,(6%) 6 women had
macroalbuminuria (as regard reference range 30-300 mg/24
h),(94%) 94women had no proteinuria and (6%) 6 women had
proteinuria (as regard reference value ≥ 300mg/24h). The mean
total microalbuminuria was88.6 mg per 24 hours (±150, range:
7-3000). The mean total proteinuria78 mg/24 hour (±90, range:
2.6-705).The mean random urinary albumin/creatinine ratio was
82.6 mg/g (±120, range 6.3-2068). The mean random urinary
protein/creatinine ratio was 0.26mg/g (±0.55, range0.01-5).The
mean serum urea nitrogen 18.90(±4.92, range 11-23). The mean
serum creatinine 0.6 (±0.22, range 0.3-1.1). The mean HbA1C 6.1
(±1.8 range 4.3 – 16).
Our study showed a significant positive correlation
between albumin/creatinine ratio in random urine sample and
each of 24-hour microalbuminuria (r=0.85, p<0.05) and 24-hour
proteinuria (r=0.20, p<0.05). There was a significant positive
correlation between 24-hour proteinuria and random urinary
protein/creatinine ratio (r=0.45, p<0.05). There was a significant
positive correlation between albumin/creatinine ratio in random
urine sample and glycosylated hemoglobin (r=0.29, p=0.04).
There was no correlation between albumin/ creatinine ratio in
random urine sample each of age (p=0.08), weight (p=0.3), BMI
(P=0.085), parity (p=0.075).There was no correlation between
protein / creatinine ratio in random urine sample and each of age
(p=0.07), weight (p0.1), BMI (P=0.15), parity (p=0.065).