الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Vascular complications of diabetes mellitus are the largest an4
most iut:ractable problems, as the rate of morbidity are strikingly increased
between diabetics due to ¥8SC’Ular di eases.
Different studies made on patients witb diabetic -.ascular di..<>eases
reported lipid metabolism aboormalities and baematological alteratiODS.
These changes may enhance the development of tbe vascular disease.
Among tbe haematological altrations in diabetic patients different
platelet function abnormalities affecting adhesion, aggregation and
release reaction were reported especially in cases with vascular diseases.
Betathromboglobulin (B-TG) is a platelet specific protein released
during platelet aggregation. Its raised level indicates in vivo platelet
activation.
In this work, plasma level of B.TG was estimated in newly diagnosed
diabetics and compared to tbat level in normal healthy individuals in
order to study the potential thrombotic risk in such patients.
The study comprised 30 newly diagnosed diabetic patients. They
were selected from diabetic outpatients clinic of Ain Shams Hospital.
They were not oo antidiabetic treatment. IS healthy individuals with
normal blood sugar level were also selected as a control group. Kidney
function tests ( specific gra’fity of urine and creatinine clearance) were
done for all subja:ts in this study and those with abnormal functions
were excluded ro avoid false rise of 8-TG resli.lts. State of diabetes
mellitus was also studied by estimation of fasting and post-prandial
blood sugar levels.
The results of plasma B-TG obtained revealed a significant rise of
its level in the diabetic group as compared to the control (P <0.01).
No correlation was found between the level of B-TG in plasma and
the blood sugar level ( r ”’ 0.3 - P > 0.05).
In cooclusion the present resli.lts pro’fide an additional e’fidence that
platelet function in diabetes mellitus is abnormal.
It is recommended to study the relationship between haematological
and biochemical abnormalities in diabetes mellitus to establish whether
platelet functioo abnormality is the cause or a consequence of vascular
endothelium disease of this disorder.