الفهرس | Only 14 pages are availabe for public view |
Abstract A light microscopic study was done on the postnatal development of the white pulp of the spleen and the cortex of mesenteric lymph nodes in the albino rat, using H & E and immunoperoxidase staining techniques. In the latter technique, monoclonal antibodies were used for identification of T and B lymphocytes. The white pulp in most of the spleens of seven-day old rats consisted of a mixture of mainly small lymphocytes with some medium-sized lymphocytes surrounding the central arterioles and forming a primitive PALS. No definite marginal zone could be detected. The majority of T cells were small lymphocytes and were concentrated around the central arterioles. B cells, most!)( in the form of medium-sized lymphocytes. were located peripherally-fin twenty-one-day old rats, the white pulp consisted of 2 zones, the PALS which is divided into a larger central area densely populated with small T lymphocytes and a smaller peripheral area containing mainly small lymphocytes and occupied by both lymphocyte populations, and the marginal zone, separating the PALS from the red pulp, which contained a large population of medium-sized B lymphocytes. Primary follicles were infrequently seen.; However, follicles formed of aggregated small B lymphocytes, as primary well as secondary follicles with pale germinal centers were observed in all |