الفهرس 
GASTRO-ESOPHAGEAL REFLUX DISEASE (GERD)Only 14 pages are availabe for public view
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Abstract
G
astroesophageal reflux disease (GERD) is the most common gastrointestinal diagnosis recorded in outpatient clinics that affects several aspects of everyday life. GERD is a condition, which develops when the reflux of stomach contents causes troublesome symptoms and/or complications. Silent gastroesophageal reflux disease (GERD) is a common disorder that manifests with erosive esophagitis in asymptomatic undergoing screening endoscopy and the severity of esophageal injury graded according to the Los Angeles classification.
This study aimed to detect the role of Helicobacter pylori infection and body mass index (BMI) in asymptomatic erosive esophagitis (AEE).
This study was performed on 60 subjects recruited from Endoscopic Unit and Internal Medicine Department of Ahmed Maher Teaching Hospital, during the period from May 2012 to June 2013.They were divided into the following two groups: Group (I): Thirty patients with no esophageal symptoms subjected to upper GIT endoscopy for other causes. Group (II): Thirty patients with esophageal symptoms (heartburn and / or regurgitation) subjected to upper GIT endoscopy.
As regard sex distribution, there were higher percentage of males (63.33%) compared to females (36.67%) in group I while in group II, the percentage of females (80%) was higher than percentage of males (20%) in the same group with statistically significant difference (p= 0.001).
As regard age, there was higher mean age in group I (43.767±12.011) compared to mean age (30.633±11.034) in group II with statistically significant difference between both study groups (p<0.001).
As regard clinical presentation, the most common reported manifestations were heartburn (93.33%), regurgitation (96.67%) and epigastric pain (46.67%) in group II with highly statistically significant difference (p=0.000). It is noted that patients complaining of heartburn and regurgitation were positive for H. pylori.
As regard BMI, high statistically significant difference between the study groups with higher BMI in group (I) compared to group (II). The relation between BMI and grades of erosive esophagitis in group (I) shows no statistically significant difference (p=0.884).
As regard endoscopic examination, 13 patients in group (I) with percentage (43.33%) had hiatus hernia while no cases with hiatus hernia in group (II) was reported. This was of highly statistically significant difference (p=0.005) between the study groups.
Regarding grades of erosive esophgitis in group (I), 18 (60%) patients had Grade A, 12 (40%) patients had grade B while grade C & D are not found. The relation between H. pylori and grades of erosive esophagitis in group (I) show statistically significant difference (p=0.05).
As regard duodenal ulcer (DU) and gastric ulcer (GU), 7 (23.33%) patients had DU in group (I) while no one had DU in group (II) and This was of highly statistically significance (p=0.001). 4 (12.5%) patients of them were positive for H. pylori and 3 (10.71%) patients were negative for H. pylori while Only 2 (6.67%) cases had gastric ulcer in group (I) and they were negative for H. pylori while no-cases had gastric ulcer in group (II). This difference was of no significance statistically (p=0.092).
As regard intestinal metaplasia, 4 (6.675%) cases in group (II) had intestinal metaplasia while all cases in group (I) did not have intestinal metaplasia. As well, all cases in both groups did not have atrophic gastritis and no statistically difference was reported.
As regard H. pylori infection, 19 (63.33%) patients were negative for H. pylori and 11 (36.67%) patients were positive for H. pylori in group (I) while in group (II), 21 (70%) patients were positive for H. pylori and 9 (30%) patients were negative for H. pylori. This was statistically significant difference (p=0.01). The relation between H. pylori and BMI shows no statistically significant difference.