الفهرس | Only 14 pages are availabe for public view |
Abstract Moringa oleifera leaves were screened for its phytochemical constituent, toxicological effects and pharmacological activities. The plant was tested for the presence of alkaloids, carbohydrates, flavonoids, resin, tannins, saponins and unsaturated sterols and /or triterpenes. The anticoccidal activity of Moringa oleifera powdered leaves and its 75 % ethanolic extract were studied on one-day old chicks. In addition, the effect of powdered leaves on the broiler performance was carried out on both control healthy and coccidia infected chicks. The oral anti-inflammatory (Formalin induced edema), antipyretic (Brewer’s yeast induced hyperthermia) and antinociceptive (Thermal and chemical induced pain) effects of the ethanolic extract of Moringa oleifera were carried out on experimental animal models. Estrogenic, progesteron and androgen like activity of the tested ethanolic extract were studied using immature female mice, immature female rabbits and immature male rats respectively. Moreover the antispasmodic activity was illustrated using isolated rabbit duodenum and isolated uterine horn of rat. The antibacterial activity against gram negative and gram positive was studied in vitro using pore method. Toxicological effect was studied using upgrading oral doses in different groups of rats with monitoring the toxicological symptoms and mortality rate. The obtained result proved that the plant leaves contain alkaloids, carbohydrates, flavonoids, resin, tannins and saponnins and free from unsaturated sterols and /or triterpenes. Moringa oleifera powder showed significant enhancement of growth. In addition Moringa oleifera powder and ethanolic extract showed marked anticoccidial activity. Oral administration of ethanolic extract showed significant anti-inflammatory, antipyretic and antinociceptive activities. Subcutaneous injection of the tested extract showed significant estrogen like activity. Moreover ethanolic extract showed remarkable antispasmodic and antibacterial activity in concentration dependent manner. There were no toxicological symptoms or mortalities obtained till oral administration of 6000 mg/kg b. wt. |