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Abstract all isolated strains were sensitive to flumequine, gentamycin, but in nitrofuration all strains were sensi tive except: strains which were belonging to 0-group 0111 were resistant. All strains were resistant to ampicill in, streptomycin tetracyclin, trimethoprim, neomycin (except 0-group 0127) and colistin except 0-group 0111 other antimicrobial agents showed variable results. This study revealed that uncontrolled use of antibiotics in poultry farms is dangerous for both poultry and human public health. The pathogenicity of the isolated E.coli sero- groups were tested by inoculation of microorganism through the oral and intra_peritoneal route in 1-day old chicks and duckl Jugs and Lhe oral route in turkey poults. In one month old chickens the microorganism was inoculated orally and intru-nasaily. The recorded mortality rate was 100% in 1-day old (chicks ducklings and turkey poults) indicating that the isolated serogroups were pathogenic in such bird. There was no clinical signs in birds which died within 24-48 hours after inoculation orally or intra- peritonealy while birds which died after 3 days showed depression, huddling together inappetance and diarrhoea. The post-mortem lesions were septicaemia (petechial haemorrhage on coronary fat in liver and spleen, conges tion of internal organs and subcutaneous blood vessels, in birds which died after 3 days showed serofibrinous or fibrinous pericarditis, perihepatitis and air saccu lids, and the reisolation of the organisms from the internal organs of died birds occurred. |