الفهرس 
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Abstract
Reaction of 4-aryl-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carbonitrile (1a,b) with glycosyl / galactosyl and lactosyl bromide afforded the corresponding N-nuclosides 2-4a,b. Acyclonucleoside 8,9a,b were otained from reaction of 1a,b with acetoxybutyl bromide, 2-acetoxyethoxymethyl bromide in presence of potassium carbonate / dry DMF. Deactylation of nucleosides 2-4a,b and acyclonucleosides 8,9a,b in presence of Et3N / MeOH and few drops of water gave the deprotected derivatives 5-7a,b and 10,11a,b in high yield. On the other hand, alkylation of 1a,b with allyl / propargyl and epichlorohydrine gave the corresponding N-alkyl derivatives 12-14, respectively. All the newly synthesized compounds elucidated by IR, 1H, 13C NMR and elemental analysis. Some of these compounds were screened for antimicrobial activates