الفهرس 
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Abstract
Thyroid hormones (THs), including tri-iodothyronine (T3) and tetra-iodothyronine (T4), are recognized as key metabolic hormones of the body, with T3 being the most functionally active form. THs are formed within the follicular cells of the thyroid gland, and are released into the systemic circulation in response to thyroid stimulating hormone (TSH). Thyroid hormones are involved in the regulation of numerous body functions including lipid and carbohydrate metabolism, oxygen consumption and several physiological functions such as development, reproduction, and growth. Alterations in their normal levels cause some biochemical and clinical abnormalities such as hypothyroidism and hyperthyroidism (Kundu et al., 2006).
The present work aims to study the effect of hypo-and hyperthyroidism on testicular function and oxidative stress parameters as well as on antioxidant defense system of adult male rats.
The study parameters were:
1. In serum: Thyroid hormones (free T3, and free T4), Thyroid simulating hormone (TSH), testosterone, Luteinizing hormone (LH), Follicle stimulating hormone (FSH), estradiol (E2) and cholesterol.
2. In testis: Malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), glutathionperoxidase (GPx), superoxide dismutase (SOD) and catalase (CAT).
3. Histopathological examination of testis isolated from experimental rats to configure the effect of hypo-and hyperthyroidism on these tissues.