الفهرس 
HepatocarcinogenesisOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide, with a recently increased incidence in Egypt. Its prognosis is still poor although many advances in its clinical study. In this work the cell cycle regulation in relation to cell proliferation, as an important determinant of tumor behavior, was evaluated in HCC, as a new aspect of interest in cancer research.
The present work evolved 40 cases with HCC, compared along the whole study with each tumor pericancerous tissue which was present in 26 of these cases. In addition, six controls with normal liver were studied.
The mean age of cancer patients was 58.4 years old and 42.5% aged between 50-60 years. The incidence was more in males with male to female ratio was 5:1.
Malignant tumors were graded into 8 well differentiated tumors, 24 moderately differentiated tumors and 8 cases poorly differentiated tumors. TNM staging was applied for each tumor case.
In this retrospective study p27 expression as well as mean AgNOR count/ nucleus as a proliferation marker was detected in HCC and correlated with different clinicopathological variants such as age, gender, size of lesion, multiplicity, presence or absence of underling cirrhosis and presence or absence of vascular invasion, grade and stage of the tumor.