الفهرس 
Age related changes in vascular systemOnly 14 pages are availabe for public view
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Abstract
Hypertension is a part of atherosclerosis occurs at
different levels of arterial system starting in large arteries as
Aorta and carotid arteries to smaller arteries which represent
resistance arteries leading to increase in the peripheral
resistance.Hypertension causes left ventricular hypertrophy and
increase aortic diameter (Safar, 1999).
Atherosclerosis is an inflammatory process begins by
endothelial injury and end by atheroma formation mediated by
several inflammatory markers including C-reactive protein and
propagated by lipid accumulation (LDL) in the atheroma
causing more endothelium injury (Izzo, 2007).
The current study is a case-control study aiming to find a
relationship between hypertension and arterial system including
aortic diameter and peripheral circulation considering other
factors Hs.C-reactive protein and dyslipidemia which are
considered risk factors for atherosclerosis .
The current study was conducted on one hundred elderly
subjects sixty years and more divided into two groups :
hypertensive group (cases) and non hypertensive group
(control) matched for age and sex.
There was significant difference between hypertensive group
and non hypertensive group regarding Blood pressure
parameters(SBP, DBP and PP).
However, There was no significant difference between
hypertensive and non hypertensive group regarding aortic root
diameter .AOD was directly related to different parameters of
arterial blood pressure.
Age was considered as a major contributer in the relation
between hypertension and AOD as mentioned later in the
literature by (Dart.,2001), this concept was emphasized by the
current study which declared that age was directly related to
AOD. Alternatively, age had a significant correlation with PP
which means that there was an intermingled relationship
between age , PP and AOD.
In addition, AOD was inversely related to ABI , But
regarding male to female difference, AOD showed insignificant
difference between hypertensive and non hypertensive ones.
In comparison between hypertensive and non
hypertensive group as regards PAD, it represent 21% in
hypertensive group vs. 12% in non hypertensive group .
There was no significant difference between participants
with PAD and participants without PAD regarding AOD or
Hs.C-reactive protein, but a significant difference was found
between hypertensive group and non hypertensive group
regarding Hs.C-reactive protein.
Besides , Hs.C-reactive protein had a significant positive
correlation with different parameters of blood pressure .Also
Hs.C-reactive protein had a positive correlation with serum
level of TG , T.CHOL/HDL ratio ,LDL and T.CHOL.
In addition , Hs.C-reactive protein was directly related to
AOD and inversely related to ABI.
The current study declared that there was a significant
difference between hypertensive and non hypertensive group in
serum level of TG, HDL,LDL,T.CHOL/HDL ratio. And
showed that serum level of LDL had a significant positive
correlation with SBP .
In Conclusion, there was no significant relation between
hypertension and either AOD or PVD, However there was a
significant correlation between hypertension and serum
hs.CRP and cardiovascular risk factors as dyslipidemia.