الفهرس | Only 14 pages are availabe for public view |
Abstract Reaction of pyrazolone derivatives (1a-g) with peracetylated glucose under microwave irradiation for 0.5-5.0 min. using silica gel as a solid support gave the corresponding N2-nucleoside (2a-c). While their acyclonucleoside derivatives (4a-c) and (6a-d) were obtained by its reaction with 4-bromobutylacetate and 2-acetoxyethoxymethyl bromide under conventional condition in presence of DMF/K2CO3 at room temperature. The deacetylation of these cyclic and acyclic nucleoside in presence of Et3N/MeOH and few DROPs of water gave the corresponding free nucleoside (3a-c), (5a-c) and (7a-d). The structure of the new compounds was confirmed by using IR, and 1H, 13C NMR spectra and microanalysis. Selected members of these compounds were screened for antimicrobial activity |