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Abstract Intrathecal opioid administration has been demonstrated to provide effective post-operative analgesia after a variety of surgical procedures at the cost of increased risk of respiratory depression. Tramadol, an opioid agonist is known to provide adequate analgesia with less respiratory depression. Animal studies have confirmed the analgesic effect of intrathecally administered tramadol but human studies establishing its efficacy are still lacking. The present study was carried out to evaluate and study clinically the efficacy in terms of duration of action and side effects of tramadol 25 mg when given intrathecally with 0.5% bupivacaine in numbers of lower abdominal surgeries. The study was conducted upon 60 patients, less than 55 years old of ASA and II classification who are operated upon for lower abdominal surgeries. The patients were randomly divided into 2 equal groups: Group S: 30 patients received 3 ml bupivacaine 0.5% intrathecally along with 0.5 ml saline. Group T: 30 patients received 3 ml bupivacaine 0.5% intrathecally along with 0.5 ml (25 mg) tramadol. In the present study, there was slight statistical significant difference in HR and BP between the two groups but not clinically significant |