الفهرس يوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
Two major objectives have been considered in the present work. The first one was to produce diclofenac hepatotoxicity model in rats. The second one was to investigate the possible protective effect of ginseng against the hepatic toxicity of diclofenac sodium.
The work was carried out using an adult female albino rats (432 rat) and adult male Newzeland rabbits (20 rabbit). Diclofenac sodium was administered orally (p.o) to rats in the different doses (10, 20, 30, 0.625, 1.25, 2.5, 5.00 and 7.5 mg/kg), interperitoneally (i.p) (10, 20, 30 and 40 mg/kg) and intramuscularly (i.m) (20, 40, 80, 120, 140, 2 and 4 mg/kg).In addition, it was administered orally (p.o) to rabbits in the dose (10 mg/kg). This drug was tested in either single or daily repetitive doses (for 3 or 7 days in rats and for 1 and 2 weeks in rabbits).Treatment by ginseng extract (50 mg/kg) to rats and (15 mg/kg) to rabbits was done in three ways, co-administered, pre-administered or post-administered with certain treatments of diclofenac sodium. The examined parameters included estimation of the serum activities of alanine aminotransferase “ALT”, alkaline phosphatase “ALP”, lactate dehydrogenase ”LDH”, total protein ”T.protein”, albumin, globulin as well as the serum albumin/globulin ratio (A/G ratio) .Also, triglycerides, hepatic lipid peroxidation (MDA), the liver/body weight ratio and the hepatic histopathological changes were determined.
The obtained results helped in identifying the most suitable parameters for evaluation of the diclofenac experimental hepatotoxicity model in rats, which include lactate dehydrogenase ”LDH”, total protein ”T.protein”, albumin, triglycerides and the level of lipid peroxidation (MDA).The results have also revealent that ginseng extract causes partial protective effect against the hepatotoxicity of diclofenac sodium.