الفهرس 
Review of Literatureيوجد فقط 14 صفحة متاحة للعرض العام
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المستخلص
This study was carried out in an attempt to throw more light on the effect
of cadmium administration on the pancreas and parotid gland of albino rat. Also,
to study the possible protective role of vitamin C (ascorbic acid).
Forty young adult albino rats weighing from 90 -110 gms in weight were
used in the present study. They were weighed and the blood sugar was measured
weekly. The animals were randomly assigned to four groups each of 10 rats as
follows:
Group I (Normal control group):
It is composed of 10 rats. Each one was administered 0.5ml physiological
saline solution daily orally by a modified plastic syringe for one month.
Group II (Ascorbic acid treated group):
It is composed of 10 rats .They received a daily dose of vitamin C (20 mg
/kg) dissolved in 0.5ml physiological saline solution daily orally for a period of
one month.
Group III (Cadmium chloride treated group):
It is composed of 10 rats .They received a daily dose of cadmium chloride
(2 mg /kg) dissolved in 0.5ml physiological saline solution daily orally for a
period of one month.
Group IV (Protected group):
It is composed of 10 rats .They received a daily dose of cadmium chloride
(2 mg /kg) dissolved in 0.5ml physiological saline solution daily orally
simultaneously with vitamin C (20 mg /kg) for a period of one month.
Rats were checked for base line blood glucose level on the day before the
start of the experiment [day 0]. In all groups, blood glucose was measured on
days 0, 7, 14, 21 and 30(day of scarification). Blood samples were obtained at
10 a.m. from the rat dorsal vein by tail snipping of non-fasting animals to determine blood glucose using a glucometer and strips. The average weight of
the animals was recorded on the same days.
At the time of scarification, animals were killed by decapitation. The
whole pancreas and the two parotid glands were quickly dissected, excised then
blotted. The tissue was subdivided into two parts (light and electron microscopic
examination).For light microscopy, immediate fixation of the pancreas and
parotid glands in either 10% formalin or 10% formol saline was done for 5-7
days. Fixation, dehydration, clearing and embedding in paraffin blocks were
done. Paraffin blocks prepared from specimens originally fixed in formalin
were cut into 4-6 um thick sections and stained with the following stains :
1- Haematoxylin and Eosin stain H. &E.
2- Masson’s trichrome stain MT
3- Periodic acid-Schiff’s reaction PAS