الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of the present investigation was to study the possible beneficial effect of estrogen replacement and/or AT1-RB on endothelial dysfunction and oxidative stress in ovariectomized rats. Forty adult female albino rats weighing 150-200 grams, each were used in this investigation. The rats were divided into the following groups: i. Normal (non-ovariectomized) group. ii. Ovariectomized non-treated group. iii. Ovariectomized-estradiol treated group. iv. Ovariectomized angiotensin ΙΙ type Ι receptor blocker treated group. v. Ovariectomized with combined estrogen and angiotensin ΙΙ type Ι receptor blocker treated group. In each of the previously mentioned groups, serum estradiol, blood pressure, serum malondialdehyde, serum total antioxidant status, vascular reactivity of aortic rings to NE and Ang II, and vascular relaxation of aortic rings to in response Ach and Na+ nitroprusside were measured. The results showed that ovariectomy caused significant increase in systolic blood pressure, serum malondialdehyde and vascular reactivity to angiotensin II, significant decrease in serum levels of estradiol, serum total antioxidant status and the vasodilator responses to acetylcholine, and insignificant change in vascular reactivity to NE and the vasodilator responses to Na+ nitroprusside when compared to corresponding values in non-ovariectomized group. |